Locator: 50826COLLEGE.
Locator: 50826ARCHIVES.
Link here.
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This is going to be a long blog and eventually I will get around to the subject: college choice in the US, but it's a blog in progress and I don't want to keep updating it, putting it in draft, and starting over, so I will post as I go along. It's for my edification for now. I'll let you know when it's finally complete. Don't read now.
Personal: Coyote Capers. Maybe more on this later. For the first time in my life I saw what was really possible! I'm still amazed. I would love to know the history -- who got it started? When and how? The importance of athletics.
Headlines from overnight:
- Number 11 hails "landmark" Trump visit. Expect to see Number 11 in DC soon.
- Number 11 sees what a protracted conflict could do to its economy;
- think Taiwan; an invasion is not the way to go
- Small mind: Senator Warren sends letter to new Fed chairman to divest portfolio.
- Has she divested her portfolio? I don't know? Did Nancy?
- Small minds: now TNYT is upset that the FBI director snorkeled with the US Navy in Hawaii, supposedly mixing business with leisure -- oh, give me a break -- it gets tedious -- at least Hunter Biden only mixed pleasure with pleasure while profiting off his dad's travels; where is Hunter these days? That snorkeling trip for the FBI director -- last year. Meanwhile, Comey and the seashells. It does get tedious.
- Starbucks may be preparing for major change.
- Yahoo!Finnace still comparing 2000 dot-com bust with current AI boom. This too gets tedious.
- Warren Buffett is clearly missed at BRK -- no, not really --
- Bill Ackman is suddenly bullish on OpenAI partner Microsoft.
- auto manufacturers seeing huge unexpected surge -- COWs
- US short-sightedness in aluminum is now making headlines -- Diet Coke particularly hard hit;
- The U.S. began moving primary aluminum manufacturing (smelting) overseas during the 1980s. Domestic production peaked in 1980 at 4.65 million metric tons and subsequently declined by over 80% as rising energy costs and global competition drove companies to build or shift smelting operations to countries with cheaper power.
- Ronald Reagan was president of the US for the entire decade, 1981 - 1989
- thank you for all your help Mr Reagan; that's why we need to MAGA
- the Chinese now account for more than 50% of global supply of aluminum
- seems like there might be a solution
- every day the strait stays closed, the less relevant the strait becomes
- Cheaper power. Hold that thought. For the next 20 years.
- Mainstream media continues to misread the Iran story: Trump has all the time in the world; Saudi Arabia does not. Iran is a lost cause. Every day the strait remains closed, the Mideast becomes less relevant. The winners: China and the US. The losers: the Mideast and the EU.
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The Human Genome Project
From Walter Isaacson's book on Jennifer Doudna:
Chapter 5: The Human Genome
- Doudna working in Jack Szostak's lab
- 1986: Harvard, genetics; Mass General Hospital
- began working at Harvard as a molecular biologist in 197
- simultaneously started his own independent research laboratory at the Sidney Farber Cancer Institute (now the Dana-Farber Cancer Institute) in Boston. He later became a full professor at Harvard in 1988 before eventually transitioning his academic lab to the University of Chicago.
- while at Harvard, 1986, Human Genome Project
- 3 billion pairs in human DNA; 20,000 genes
- Cold Spring Harbor Laboratory: James Watson and his son Rufus Watson;
- the younger, schizophrenic; led the elder to starting what would later become the human genome project;
- in the 1940s, phages -- Salvador Luria and Max Delbrück led a study group on phages that included the young Watson. He returned as director, Cold Spring Harbor, 1968 - 2007.
- Human Genome Project
- launched 1990
- Watson: first director
- major players: Eric Lander, Craig Venter, Francis Collins
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Eric Lander
p. 39
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Craig Venter
p. 39
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James Watson
Query:
How did James Watson end up at Cold Spring Harbor Laboratory in the 1940s?
Reply:
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Apple
Two queries:
Apple is famous for sourcing its entire lineup under one company umbrella -- from the smallest wearables to the largest personal laptops -- from intenal components -- memory, TNPs, CPUs -- does any other personal computer manufacturer come close?
Last paragraph in the reply:
Why nobody else copies the "Apple Model" The PC industry evolved on a modular model (the "Wintel" era) where specialization is highly efficient. Companies like Dell or HP act as assemblers of third-party parts, which keeps costs down and avoids the astronomical Research & Development (R&D) costs required to design proprietary CPUs, custom batteries, and proprietary operating systems (like macOS or iOS) all under one company umbrella.That's interesting -- that last paragraph -- why nobody else copies the "Apple Model" -- the high cost of R&D. Most recently it sounds like Apple made a huge and wise choice to deviate from this business model, by outsourcing all AI to established AI leaders, whereas Apple focuses on EDGE, a way of keeping AI under its (Apple's) control and the control of its customers.
