The most recent portfolio was received and posted yesterday. Already it is on the top ten list of favorite posts -- based on number of hits and "pace" of hits.
Update: a couple of hours later, now 12:57 p.m. Central Time, Vern Whitten's photographs are now #3 on the list of top 10 posts. Pretty incredible how fast his photographs move up the favorite list.
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The Amazon Page
I'll get back to this article later. Perhaps. From Bloomberg Business.
Did I mention the other day that I ordered three items from Amazon on Saturday, this past weekend. I placed the order after reading a book review in The Wall Street Journal, about noon Saturday. On Sunday, Prime Shipping, the USPS brought the book to our apartment complex -- less than 24 hours later. Delivery was guaranteed to be no later than two days, Monday night by 8:00 p.m. It was at the apartment complex by noon Sunday.
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A Note For The Granddaughters
The Human Genome
Nature: The Human Genome
Editor: Carina Dennis and Richard Gallagher
c. 2001
DDS: 599.935 HUM
Pages 892+.
It is noteworthy that CRISPR-cas9 is not mentioned in this book.
Thousands of human genes produce noncoding RNAs (ncRNAs) as their ultimate product. Examples of ncRNAs:
- transfer RNAs (tRNAs)
- ribosomal RNAs (rRNAs)
- small nucleolar RNAs (snoRNAs)
- small nuclear RNAs (snRNAs)
- humans have both a major and a minor spliceosome
- major: U2 snRNA-dependent spliceosome, splices most intron
- minor: U12 snRNA-dependent spliceosome, splices a rare class of introns that often have AT/AC dinucleotides at the splice sites instead of the canonical GT/Ag splice site consensus
- telomerase RNA
- 7SL signal recognition particle RNA
- a large Xist transcript implicated in X dosage compensation; enigmatic function
- small vault RNAs found in the bizarre vault ribonucleoproten complex, which is 3x the mass of the ribosome but has unknown function
- ncRNAs are very, very difficult to find using current techniques; even if the complete finished sequence of the human genome were available, discovering novel ncRNAs would still be challenging
- BLASTN technique: used to identify genomic sequences that are homologous to known ncRNA genes
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