Monday, August 3, 2020

Got Steak? Covid Clinical Trial: The Trump Cocktail -- Hydroxychloroquine, Steak, And Azithromycin

From clinicaltrials.gov, link here:

Clinical trial:
  • hydroxychloroquine + steak + antibiotic (azithromycin or doxycycline)
  • 750 participants
  • test dates:
    • start date: April 28, 2020
    • estimated primary completion date (when results of the study will be leaked): September 3, 2020
    • estimated study completion date (when massaged results of the study will be officially released): December 31, 2020
Detailed description of this study:
COVID-19 is an aggressive and contagious virus, found to have high mortality especially in persons with comorbidities (age>60, hypertension, diabetes mellitus, cancer, and otherwise immunocompromised). 
Zinc is a supplement with possible antiviral properties, having been shown to have effect in the common cold, many of which are due to coronavirus. 
In addition, elderly patients and patients with co-morbidities have high incidence of zinc deficiency. 
We are repleting zinc in all patients and studying its direct effect in combination with hydroxychloroquine, and an antibiotic, either azithromycin or doxycycline to see if there is enhanced treatment efficacy in early COVID-19 infection and assess the safety of these two regimen.
Re: zinc.

From one source -
Zinc supports the production and maturation of white blood cells, which are the major players in the immune system. There are multiple types of white blood cells, some of which make antibodies, capture and destroy pathogens, and return the immune system to normal after an infection. Zinc also helps to regulate inflammation. While an inflammatory response is necessary to fight infection, the overproduction of pro-inflammatory cytokines early in the infection is responsible for some of the worst symptoms of COVID-19. The review describes evidence showing that zinc may have an anti-inflammatory effect in pneumonia, limiting the damage to lung tissue. For decades, scientists have known that zinc can block the replication of rhinoviruses responsible for respiratory infections in people, including the common cold. Higher levels of zinc in cells help block the reproduction of rhinoviruses and stimulate interferon alfa production. This signaling molecule prompts nearby cells to initiate their anti-viral defenses. The review also found evidence specific to coronaviruses. One study showed that zinc blocks the enzyme responsible for replicating the coronavirus that led to the SARS outbreak of 2002.
From another source:
Interestingly, chloroquine — which some people suggested as a treatment option early on in the pandemic – increases the cells uptake of zinc, which may underlie some of its positive effects. A 2020 study showed that when doctors treated patients with zinc and hydroxychloroquine, they discharged more patients, and fewer people died from COVID-19 Foods high in zinc include animal products, such as beef, shellfish, dark-meat chicken, and fortified breakfast cereal. However, beans, nuts, and seeds also contain zinc. Phytates in vegetables and grains can reduce the absorption of zinc and, therefore, vegetarians and vegans may need 50% more zinc in their diet.
Re: Covid and those with underlying co-morbidities -- add "vegans" to that list.

Question: What can vegans do to get off the list of "underlying co-mordibities" and Covid-19?

Answer: McDonald's once a day and a Weber grill / t-bone steak on the weekend. This is not rocket science.

Sources of zinc:
Zinc is a water-soluble nutrient - so you need to replenish it every day. Here's what you can eat to get 100% of your daily requirement - eat the item on one line and you're set:
  • 1 1/2 oysters (so each oyster is 66% of your requirement - powerful!)
  • 1 large king crab leg
  • 10 ounces lobster meat
  • 4 ounces beef steak
  • 8 ounces hamburger
  • 2 complete chicken thighs and legs (all the dark meat from one chicken)
  • 3 cups firm tofu (tofu is a 4-letter word)
  • 9 ounces of pork steak (beef is twice as good)
  • 7 ounces of cashews
  • 5 cups of cooked lentils, beans, garbanzos etc. See above: a vegetarian may need 7 1/2 cups
  • 10 ounces hard cheese
  • 10 poached eggs
  • 5 cups of yogurt, or oatmeal or mushrooms
  • over 2 pounds of fish such as salmon, tuna, pike, mackerel
  • over 2 pounds of chicken breast or turkey breast
That's every day.

4 comments:

  1. A good Montana steak will cure just about everything- Especially your hunger

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    Replies
    1. Speaking of which ... my nephew grilled New York strip steaks out at Flathead Lake earlier this evening --- steaks from Costco; most of rest sides from Rossauer's (spelling?).

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  2. Rosauers. But wont hold it against you. Costco gets their beef local and I love the extra thick cuts. With just the wife and I we can get twice the meals with every cut.

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    Replies
    1. Don't even get me started. I pleaded with them to go to Costco, but it was "too far away" -- other side of town and would go nowhere but Rosauers (thank you; I had the spelling wrong). I was not a happy camper. LOL. But at least we got beef. LOL. And zinc.

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